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Speaking on a conference call, Chief Financial Officer David Meline said Amgen faces headwinds in the form of competition for legacy products such as kidney drug Sensipar and rheumatoid arthritis treatment Enbrel as well as heightened U.S. focus on the issue of prescription drug affordability. He said Amgen’s 2019 outlook assumes its global net sales prices will drop by a rate in the “mid-single digits” after falling 1 percent in 2018. Excluding items, Thousand Oaks, California-based Amgen posted adjusted quarterly earnings of $3.42 per share, topping analysts’ average expectations by 15 cents.

Revenue for the quarter rose 7 percent to $6.23 billion, beating the average analyst estimate of $5.84 billion, “The fourth quarter was black mother of pearl collar stays cufflinks a very strong result,” said Jefferies analyst Michael Yee, “The (2019) guidance reflects an expected year of uncertainty and some lack of visibility” regarding competition from cheaper biosimilar versions of white-blood-cell booster Neulasta and Enbrel - Amgen’s two biggest-selling products, Amgen’s forecast appears to be part of an emerging trend among large drugmakers, Earlier on Tuesday, Pfizer Inc issued a 2019 earnings forecast well below Wall Street estimates, That followed lower-than-expected initial full-year earnings outlooks from Johnson & Johnson and Bristol-Myers Squibb Co..

However, Yee noted that Amgen has historically issued conservative financial forecasts at the beginning of the year, before raising them each quarter as actual results are reported. The increase in Amgen’s fourth-quarter sales was driven largely by demand for medicines such as cancer drug Kyprolis, cholesterol fighter Repatha and osteoporosis treatment Prolia. Sales of new migraine drug Aimovig totaled $95 million for the quarter, nearly double the $50 million analysts had forecast. Aimovig was first to market among a new class of drugs designed to prevent rather than treat migraine headaches.

(Reuters) - Harley-Davidson Inc reported worse-than-expected quarterly profit on Tuesday and forecast black mother of pearl collar stays cufflinks a slump in global shipments of its motorcycles in 2019, sending its shares down 5 percent, Still, to avoid the fallout of a tariff war waged by U.S, President Donald Trump, the American company said it would boost investment at its Thailand plant to serve European markets, Such a move would allow its motorbikes to avoid retaliatory tariffs by the European Union on U.S, imports, The news on the Thailand facility was made public hours after Harley-Davidson reported a fourth straight year of declines in worldwide sales, The company has been struggling to revive demand in the United States, which accounts for nearly 60 percent of total sales..

The company expects to ship up to 222,000 motorcycles globally in 2019, the lowest number since 2010. Shares closed $1.85 lower at $34.76. The stock of the Milwaukee, Wisconsin-based company has fallen about 30 percent since the beginning of 2018. The motorbike maker said tariffs alone, including import duties imposed by the European Union on its motorcycles, would amount to between $100 million and $120 million in 2019 and contribute to a 6-percentage-point drop in operating margins in the first quarter of this year.

Operating margins in the fourth quarter declined 6.2 percentage points, in part due to the tariffs, Operating margins measure how much profit a company makes on a dollar of sales, The company will invest $15 million to expand the Thai facility in black mother of pearl collar stays cufflinks the city of Rayong, and shipments to Europe will begin by the end of 2019, The plant was originally intended to serve Southeast Asian and Chinese markets, The decision to shift production out of the United States for European markets was announced last summer after the EU slapped tariffs on U.S, imports in response to Trump’s duties on steel and aluminum imports from the trading bloc..

Trump had blasted Harley’s decision and publicly backed a boycott of the company. His comments have compounded financial troubles in the United States for the company, as its core customers grow older and outreach efforts to lure younger riders have yet to show results. A survey published last week by market research firm YouGov found that Trump’s attack led to an erosion in Harley’s brand impression among its core customers. Harley-Davidson reported an adjusted profit of 17 cents per share in the fourth quarter, lower than the 28 cents estimated by analysts polled by Refinitiv.

(Reuters) - Another government shutdown could inflict greater harm on the U.S, economy, especially it were to happen only three weeks after the end of the longest ever such closure, Moody’s Investors Service said on Tuesday, “If another shutdown occurs, there could be a more severe impact on the U.S, economy than during the recently ended shutdown,” the rating agency said in a statement, The recent shutdown began in late December after U.S, President black mother of pearl collar stays cufflinks Donald Trump refused to sign a bill to fund the government as he demanded $5.7 billion for building a wall along the border between the United States and Mexico..

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